A Synergy Note:Â Following is another excellent article by Mark Sisson. This one discusses Testosterone Replacement Therapy for women.
At Synergy, our hormone therapy doctors have been replacing women’s testosterone to optimal levels since 2007. A significant portion of our women patients on testosterone therapy have reported better workouts; more energy, drive and motivation; and better libido. Not every woman needs testosterone, however. It does not always decrease with menopause like estrogen does. That’s why we check blood levels and correlate them with your symptoms to come up with a personalized plan for each individual.
Testosterone Replacement Therapy isn’t only for men
By Mark Sisson – May 2025
Friendly reminder that Testosterone Replacement Therapy isn’t only for men. While older men stand to benefit most from testosterone replacement, the effects of drastically lower testosterone can also have a subtle but disastrous effect on libido, mood, and overall well-being in postmenopausal women.
My wife, Carrie, who has used bioidentical hormone replacement therapy for a long time, includes in her regimen a small dose of testosterone. This was a later addition than all the other stuff she was using, and it’s been a revelation for her (and me).
I’ve always maintained that physical intimacy is an enormous part of a relationship. The notion that sex stops mattering the longer the relationship goes on and the older its participants get isn’t just incorrect. It’s completely backwards. Good sex deepens the relationship. It makes the rest of the relationship work better.
And so, after consulting study after study that all found that a small dose of testosterone replacement in women after menopause had a reliable and consistent effect on libido and relationship satisfaction, she tried it. Because it is replacement. Before menopause, women do produce a decent amount of testosterone. Not a large absolute amount, but they are sensitive to it. It plays a big role.
So to any older woman who wishes she had the libido she once had, talk to your doctor about testosterone replacement. I’d even go so far as to say that if an older husband has decided to take TRT to improve his cognitive function, physique, and overall sense of well-being, his wife should consider it as well. The two go hand in hand. It helps them bond and meld together. Helps them get on the same page.